Los Angeles Cancer Surveillance Program, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Int J Cancer. 2012 Jan 15;130(2):395-404. doi: 10.1002/ijc.26004. Epub 2011 Apr 25.
Racial/ethnic disparities in breast cancer incidence may contain important evidence for understanding and control of the disease. Monitoring the incidence trends of breast cancer by race/ethnicity allows identification of high risk groups and development of targeted prevention programs. Using population-based cancer registry data from the Los Angeles Cancer Surveillance Program, we examined the invasive female breast cancer incidence trends among the diverse racial/ethnic populations in Los Angeles County, California, from 1972 to 2007. Age-adjusted incidence rates (AAIRs) and age-specific incidence rates (ASIRs) were calculated and examined respectively for non-Hispanic (NH) white, black, Hispanic, Chinese, Filipina, Japanese and Korean women by calendar year and time period. Rising trends of AAIRs were found in all racial/ethnic groups during the 1980s and 1990s. The breast cancer risk increased more substantially in Japanese and Filipinas than in Chinese and Koreans. During 2000-2007, the trends of AAIRs declined significantly among NH white women and slightly in blacks, remained unchanged for Hispanics and continued to rise significantly among all Asian subgroups. The patterns of ASIRs by race/ethnicity changed dramatically over time. By 2000-2007, younger Hispanic women had the lowest breast cancer risk, replacing the Chinese and Koreans who formerly had the lowest risk. Rapidly increasing breast cancer incidence trends among Asian-Americans underline the importance of behavioral and lifestyle changes as a result of acculturation on the development of the disease. The unique trends of breast cancer incidence by race/ethnicity suggest the need for targeted breast cancer control programs for different racial/ethnic populations.
种族/民族差异在乳腺癌发病率中可能包含着了解和控制疾病的重要证据。通过种族/民族监测乳腺癌发病率趋势，可以确定高危人群，并制定有针对性的预防计划。利用洛杉矶癌症监测计划的基于人群的癌症登记数据，我们检查了加利福尼亚州洛杉矶县不同种族/民族人群中女性浸润性乳腺癌的发病率趋势，时间范围为 1972 年至 2007 年。分别按日历年度和时间段计算了非西班牙裔（NH）白种人、黑种人、西班牙裔、华裔、菲律宾裔、日裔和韩裔女性的年龄调整发病率（AAIR）和年龄特定发病率（ASIR）。在 20 世纪 80 年代和 90 年代，所有种族/民族群体的 AAIR 均呈上升趋势。与华裔和韩裔相比，日裔和菲律宾裔的乳腺癌风险增加得更为显著。在 2000-2007 年期间，NH 白种女性的 AAIR 趋势显著下降，黑人的 AAIR 趋势略有下降，西班牙裔的 AAIR 保持不变，所有亚裔亚组的 AAIR 继续显著上升。按种族/民族划分的 ASIR 模式随时间发生了巨大变化。到 2000-2007 年，年轻的西班牙裔女性乳腺癌风险最低，取代了以前风险最低的华裔和韩裔。亚裔美国人乳腺癌发病率迅速上升，强调了由于文化融合导致行为和生活方式改变对疾病发展的重要性。不同种族/民族乳腺癌发病率的独特趋势表明，需要为不同的种族/民族人群制定有针对性的乳腺癌控制计划。
