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[接触式Nd:YAG激光照射大鼠背部皮肤伤口愈合的定量研究]

[Quantitative studies on wound healing of the dorsal skin of rats after Nd:YAG laser irradiation with contact method].

作者信息

Kaneko M

机构信息

The First Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.

出版信息

Aichi Gakuin Daigaku Shigakkai Shi. 1990 Sep;28(3):857-75.

PMID:2135141
Abstract

This paper describes the relation between differences in output power and tissue repair in Nd:YAG laser contact irradiation. Conventionally, pathological research is carried out on tissue repair, but, this paper additionally reports the cell kinetic index measured quantitatively. For irradiation conditions, the output power at the end of the handpiece was set at 3 W, 5 W, 7 W and 9 W and exposure time for all of these was set at 1 second. The following results were obtained: 1) A difference was found between the 3 W group and the other 3 groups pathologically in the early period of wound healing. In the 5 W, 7 W and 9 W groups the output power made no particular difference. 2) Pathologically, the epithelial junction was complete in the 3 W group on the 4th day after irradiation, in the 5 W group on the 7th day and in the 7 W and 9 W groups on the 14th day. 3) Pathologically, the effect of the laser irradiation appeared to end in the 3 W group on the 14th day, in the 5 W group on the 21st day, and in the 7 W and 9 W groups on the 28th day. 4) On the 1st day after irradiation in all groups, the cell kinetic index was maximum at 0.5 mm-2.0 mm away from the wound and not at the regenerated epithelial edges. 5) In all processes for the 3 W group, the cell kinetic index was lower than the other 3 groups. But, among the 5 W, 7 W and 9 W groups there were no particular differences. 6) The cell kinetic index returned to the normal range in all fields in the 3 W and 5 W groups on the 21st day and in the 7 W and 9 W groups on the 28th day. A difference was seen between the 3 W group and the other 3 groups as a result of the cell kinetic index and pathological study. Differences related to the output power in the 5 W, 7 W and 9 W groups were not observed.

摘要

本文描述了Nd:YAG激光接触照射时输出功率差异与组织修复之间的关系。传统上,组织修复的研究是通过病理学研究进行的,但本文还额外报告了定量测量的细胞动力学指标。对于照射条件,将手持件末端的输出功率设置为3W、5W、7W和9W,所有这些的照射时间均设置为1秒。获得了以下结果:1)在伤口愈合早期,3W组与其他3组在病理学上存在差异。在5W、7W和9W组中,输出功率没有特别差异。2)病理学上,照射后第4天3W组的上皮连接完整,第7天5W组的上皮连接完整,第14天7W和9W组的上皮连接完整。3)病理学上,激光照射的效果在第14天在3W组中似乎结束,在第21天在5W组中结束,在第28天在7W和9W组中结束。4)在所有组照射后的第1天,细胞动力学指标在距伤口0.5mm - 2.0mm处最大,而不在再生上皮边缘处。5)在3W组的所有过程中,细胞动力学指标低于其他3组。但是,在5W、7W和9W组之间没有特别差异。6)在第21天,3W组和5W组的所有区域以及在第28天,7W组和9W组的所有区域中,细胞动力学指标恢复到正常范围。由于细胞动力学指标和病理学研究,3W组与其他3组之间存在差异。未观察到5W、7W和9W组中与输出功率相关的差异。

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