Reece Hayley A, Levendis Demetrius C
Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits 2050, South Africa.
Acta Crystallogr C. 2008 Mar;64(Pt 3):o105-8. doi: 10.1107/S0108270107066279. Epub 2008 Feb 9.
Gabapentin [or 1-(aminomethyl)cyclohexaneacetic acid], C(9)H(17)NO(2), exists as a zwitterion [1-(ammoniomethyl)cyclohexaneacetate] in the solid state. The crystal structures and bonding networks of two new monoclinic polymorphs (beta-gabapentin and gamma-gabapentin) are studied and compared with a previously reported gabapentin polymorph [alpha-gabapentin: Ibers (2001). Acta Cryst. C57, 641-643]. All three polymorphs have extensive networks of hydrogen bonds between the NH(3)(+) and COO(-) groups of neighbouring molecules. In beta-gabapentin, there is an additional weak intramolecular hydrogen bond.
加巴喷丁[即1-(氨甲基)环己烷乙酸]，化学式为C(9)H(17)NO(2)，在固态时以两性离子[1-(氨甲基)环己烷乙酸盐]形式存在。研究了两种新的单斜晶多晶型物（β-加巴喷丁和γ-加巴喷丁）的晶体结构和键合网络，并与之前报道的加巴喷丁多晶型物[α-加巴喷丁：伊伯斯（2001年）。《晶体学报》C57卷，641 - 643页]进行了比较。所有三种多晶型物在相邻分子的NH(3)(+)和COO(-)基团之间都有广泛的氢键网络。在β-加巴喷丁中，还存在一个额外的弱分子内氢键。
