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[网络药理学:药物发现的新指南]

[Network pharmacology: new guidelines for drug discovery].

作者信息

Liu Ai-lin, Du Guan-hua

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

出版信息

Yao Xue Xue Bao. 2010 Dec;45(12):1472-7.

Abstract

The development of new drug is not only the main driving force for the development of pharmaceutical industry, but also plays a very important role in the social development. However, with the increasing demands, new drug development is facing great difficulties in recent years. The hypothesis of highly selective single-target is meeting the challenges because of its limitations. Network pharmacology has been one of the new strategies for new drug discovery based on single-target drug research in recent years. This paper focused on the basis of network pharmacology and its research progress, discussed its development direction and application prospects, and analyzed its limitations and problems as well. The application of network pharmacology in new drug development is discussed by comparing its guidelines with those of traditional Chinese medicine theory and Effective Components Group hypothesis of Chinese medicines.

摘要

新药研发不仅是制药行业发展的主要驱动力,而且在社会发展中也起着非常重要的作用。然而,随着需求的不断增加,近年来新药研发面临着巨大的困难。高选择性单靶点假说因其局限性正面临挑战。网络药理学已成为近年来基于单靶点药物研究的新药发现新策略之一。本文聚焦于网络药理学的基础及其研究进展,探讨了其发展方向和应用前景,并分析了其局限性和问题。通过将网络药理学的指导原则与中医理论及中药有效成分组假说的指导原则进行比较,讨论了网络药理学在新药研发中的应用。

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