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Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment.用于中医药的网络药理学数据库:综述与评估
Front Pharmacol. 2019 Feb 21;10:123. doi: 10.3389/fphar.2019.00123. eCollection 2019.
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A Systems Biology-Based Approach to Uncovering Molecular Mechanisms Underlying Effects of Traditional Chinese Medicine Qingdai in Chronic Myelogenous Leukemia, Involving Integration of Network Pharmacology and Molecular Docking Technology.基于系统生物学的方法揭示中药青黛治疗慢性髓性白血病作用的分子机制,涉及网络药理学和分子对接技术的整合。
Med Sci Monit. 2018 Jun 23;24:4305-4316. doi: 10.12659/MSM.908104.
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[Network pharmacology study of effective constituents of traditional Chinese medicine for Alzheimer’s disease treatment].[用于治疗阿尔茨海默病的中药有效成分的网络药理学研究]
Yao Xue Xue Bao. 2016 May;51(5):725-31.
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Network Medicine for Alzheimer's Disease and Traditional Chinese Medicine.网络医学与阿尔茨海默病和中医药。
Molecules. 2018 May 11;23(5):1143. doi: 10.3390/molecules23051143.
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Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer's disease.基于网络药理学的脑得生方治疗阿尔茨海默病的作用机制分析。
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Uncovering the Pharmacological Mechanism of Astragalus Salvia Compound on Pregnancy-Induced Hypertension Syndrome by a Network Pharmacology Approach.基于网络药理学方法揭示黄芪丹参复方治疗妊娠高血压综合征的药理机制。
Sci Rep. 2017 Dec 4;7(1):16849. doi: 10.1038/s41598-017-17139-x.
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In silico-based screen synergistic drug combinations from herb medicines: a case using Cistanche tubulosa.基于计算机的草药协同药物组合筛选:以肉苁蓉为例。
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Network pharmacology-based approach of novel traditional Chinese medicine formula for treatment of acute skin inflammation in silico.基于网络药理学的新型中药配方治疗急性皮肤炎症的计算机模拟研究
Comput Biol Chem. 2017 Dec;71:70-81. doi: 10.1016/j.compbiolchem.2017.08.013. Epub 2017 Sep 14.
9
[Application of drug-target prediction technology in network pharmacology of traditional Chinese medicine].药物靶点预测技术在中药网络药理学中的应用
Zhongguo Zhong Yao Za Zhi. 2016 Feb;41(3):377-382. doi: 10.4268/cjcmm20160303.
10
Design of new traditional Chinese medicine herbal formulae for treatment of type 2 diabetes mellitus based on network pharmacology.基于网络药理学的治疗2型糖尿病的新型中药复方设计
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网络药理学在中医药研究中的应用

Applications of Network Pharmacology in Traditional Chinese Medicine Research.

作者信息

Zhou Zhuchen, Chen Bing, Chen Simiao, Lin Minqiu, Chen Ying, Jin Shan, Chen Weiyan, Zhang Yuyan

机构信息

School of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.

School of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.

出版信息

Evid Based Complement Alternat Med. 2020 Feb 14;2020:1646905. doi: 10.1155/2020/1646905. eCollection 2020.

DOI:10.1155/2020/1646905
PMID:32148533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7042531/
Abstract

Human diseases, especially infectious ones, have been evolving constantly. However, their treatment strategies are not developing quickly. Some diseases are caused by a variety of factors with very complex pathologies, and the use of a single drug cannot solve these problems. Traditional Chinese Medicine (TCM) medication is a unique treatment method in China. TCM formulae contain multiple herbs with multitarget, multichannel, and multilink characteristics. In recent years, with the flourishing development of network pharmacology, a new method for searching therapeutic drugs has emerged. The multitarget action in network pharmacology is consistent with the complex mechanisms of disease and drug action. Using network pharmacology to understand TCM is an emerging trend.

摘要

人类疾病,尤其是传染病,一直在不断演变。然而,它们的治疗策略却没有快速发展。有些疾病是由多种因素引起的,病理非常复杂,使用单一药物无法解决这些问题。中药是中国独特的治疗方法。中药方剂包含多种具有多靶点、多途径和多环节特点的草药。近年来,随着网络药理学的蓬勃发展,出现了一种寻找治疗药物的新方法。网络药理学中的多靶点作用与疾病和药物作用的复杂机制相一致。利用网络药理学来理解中药是一个新兴趋势。