Huang Haiyan, Zhuang Zhixiong, Liu Jianjun, Xi Renrong, Xing Xiumei
Toxicology Laboratory, Shenzhen Center for Disease Control and Prevention, Shenzhen 518020, China.
Wei Sheng Yan Jiu. 2010 Nov;39(6):764-6.
To determine the expression of glutathione transferase omega 1 (GSTO-1) during hormesis induced by low dose trichloroethylene (TCE).
Based on the dose-response of hormesis induced by TCE, the total protein and mRNA from four groups was extracted, and expression of GSTO-1 was detected by western blotting and RT-PCR technology.
The study showed that increases of GSTO-1 protein expression were induced by TCE at low dose (0.1 mmol/L) TCE, but there was no significant different between the high-dose group and the control (P < 0.05). RT-PCR analysis presented the expression of GSTO-1 gene in low-dose group was increased, but the opposite effect was observed in the high-dose group.
GSTO-1 may be play a key role in hormesis induced by TCE.
