Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Early Interv Psychiatry. 2008 Aug;2(3):147-53. doi: 10.1111/j.1751-7893.2008.00078.x.
In early detection work, recruiting individuals who meet the prodromal criteria is difficult. The aim of this paper was to describe the development of a research clinic for individuals who appear to be at risk of developing a psychosis and the process for educating the community and obtaining referrals.
The outcome of all referrals to the clinic over a 4-year period was examined.
Following an ongoing education campaign that was over inclusive in order to aid recruitment, approximately 27% of all referrals met the criteria for being at clinical high risk of psychosis.
We are seeing only a small proportion of those in the community who eventually go on to develop a psychotic illness. This raises two important issues, namely how to remedy the situation, and second, the impact of this on current research in terms of sampling bias and generalizability of research findings.
在早期检测工作中，招募符合前驱期标准的个体具有一定难度。本文旨在描述一个为有发展为精神病风险的个体设立的研究门诊的发展情况，以及向社区进行教育和获得转诊的过程。
对诊所 4 年来的所有转诊患者的结局进行了研究。
通过一项持续的、范围广泛的教育活动来辅助招募，约 27%的转诊患者符合处于精神病前驱期的临床高风险标准。
我们只看到了社区中最终会发展为精神病的一小部分患者。这引发了两个重要问题，即如何改善这种情况，以及这种情况对当前研究中采样偏差和研究结果可推广性的影响。
