From the Department of Pediatrics, University of Chieti, Chieti, Italy (S. De Sanctis, L. Breda, M. Nozzi, M. Del Torto, F. Chiarelli, and A. Verrotti); Laboratory of Neurogenetics, IRCCS National Neurological Institute "C. Mondino," Pavia, Italy (G.S. Grieco); Department of Neurology and ORL, Sapienza University of Rome-Polo Pontino, Latina, Italy (C. Casali).
Headache. 2011 Mar;51(3):447-450. doi: 10.1111/j.1526-4610.2010.01793.x. Epub 2010 Nov 4.
Hemiplegic migraine is a rare form of migraine characterized by periodic attacks of migraine with neurologic aura and transient hemiplegia. There are familial and sporadic cases, both on a genetic basis; we describe the case of a 6-year-old boy affected by sporadic hemiplegic migraine, showing a novel ATP1A2 gene missense mutation (p.Gly715Arg) in exon 16. Long-term treatment with flunarizine resulted in good clinical response and prevention of further attacks.
偏瘫性偏头痛是一种罕见的偏头痛形式，其特征为周期性偏头痛伴神经症状和短暂性偏瘫发作。该病有家族性和散发性病例，均基于遗传基础；我们描述了一例 6 岁散发性偏瘫性偏头痛男孩的病例，该男孩在第 16 外显子中存在 ATP1A2 基因突变（p.Gly715Arg）。长期氟桂利嗪治疗可获得良好的临床反应和预防进一步发作。
