Service de recueil et analyse des effets indésirables, Centre National de Pharmacovigilance, 9 Av Dr Zouheir Essafi 1006 Tunis, Tunisia.
Fundam Clin Pharmacol. 2012 Apr;26(2):207-9. doi: 10.1111/j.1472-8206.2010.00914.x. Epub 2011 Feb 24.
Cardiac adverse effects have never been reported with interferon (INF) beta. We report a case of left bundle branch block in a 35-year-old woman treated with INF beta-1a for multiple sclerosis. Five years after INF therapy, she presented loss of consciousness, retrosternal pains, short breath and lowered tolerance of effort. ECG and Holter 24-h ECG monitoring revealed permanent complete left bundle branch block. Nine months after stopping INF, no abnormalities were found at ECG and echocardiogram examination.
心脏不良反应从未在干扰素（INF）β治疗中报告过。我们报告了一例 35 岁女性因多发性硬化症用 INFβ-1a 治疗后出现左束支传导阻滞。INF 治疗 5 年后，她出现意识丧失、胸骨后疼痛、呼吸急促和活动耐量降低。心电图和 24 小时动态心电图监测显示永久性完全性左束支传导阻滞。停止 INF 治疗 9 个月后，心电图和超声心动图检查未见异常。
