Wegener S, Jakubik E, Schmidt M
Bezirks-Institut für Blutspende- und Transfusionswesen Rostock.
Dtsch Z Mund Kiefer Gesichtschir. 1990 Sep-Oct;14(5):378-82.
HLA typing of 50 patients with cleft lip and/or cleft palate (50 HLA-ABC and 35 HLA-DR tests) and, in part, also of their families showed an increased frequency of the antigens HLA-AII, DRw6 and the haplotype HLA-A11, B35 as against the normal population. Disorders of wound healing were observed more frequently in patients with HLA antigens A11 and B15 than in those without these antigens. Based on these hints of an HLA association (p values after correction are not significant), and the frequent coincidence of HLA-DR antigen in the patients' parents, as well as the increased rate of HLA-DR homozygosity of the patients, it is assumed that genetic factors of the HLA complex or an HLA-linked complex play a part in the etiology of clefts of the lip and cleft palate.
对50例唇裂和/或腭裂患者进行了HLA分型（50次HLA - ABC检测和35次HLA - DR检测），部分患者及其家属也进行了检测，结果显示与正常人群相比，抗原HLA - A11、DRw6及单倍型HLA - A11、B35的频率有所增加。观察发现，具有HLA抗原A11和B15的患者伤口愈合障碍比没有这些抗原的患者更常见。基于这些HLA关联的线索（校正后的p值无统计学意义），以及患者父母中HLA - DR抗原的频繁巧合，还有患者中HLA - DR纯合子率的增加，推测HLA复合体的遗传因素或与HLA连锁的复合体在唇裂和腭裂的病因中起作用。
