Van Dyke D C, Goldman A S, Spielman R S, Zmijewski C M, Oka S W
Cleft Palate J. 1980 Jul;17(3):189-93.
The segregation of HLA haplotypes (A, B, and C loci) was studied in eight families in which two sibs were affected with cleft lip or cleft lip and palate. HLA typing was performed in parents and sibs and in specific cases, other family members. Segregation of HLA haplotypes did not differ significantly from random Mendelian expectation. Three of the eight affected sib pairs differed in both HLA haplotypes, which is not expected if there is close linkage with susceptibility to clefting. Thus, it is very unlikely that spontaneous cleft lip or cleft lip and palate is closely linked to HLA.
在八个家庭中研究了HLA单倍型（A、B和C位点）的分离情况，这些家庭中有两个兄弟姐妹患有唇裂或唇腭裂。对父母、兄弟姐妹以及特定情况下的其他家庭成员进行了HLA分型。HLA单倍型的分离与随机孟德尔预期无显著差异。八个受影响的兄弟姐妹对中有三个在HLA单倍型上均不同，如果与腭裂易感性存在紧密连锁，这是不符合预期的。因此，自发唇裂或唇腭裂与HLA紧密连锁的可能性非常小。
