Bonner J J, Terasaki P I, Thompson P, Holve L M, Wilson L, Ebbin A J, Slavkin H C
Tissue Antigens. 1978 Sep;12(3):228-32. doi: 10.1111/j.1399-0039.1978.tb01328.x.
The HLA types of 133 patients with cleft lip and/or cleft palate were determined. Caucasian patients with isolated cleft palate showed a possible association with HLA. Ten of 11 male patients had HLA--A2 as compared to one out of eight female patients (P less than 0.005). Caucasian males with cleft lip and cleft palate had a slight increased frequency of HLA--Aw24 (P = 0.07) and Mexican-American males with cleft lip and/or cleft palate showed an increase of antigen HLA-A28 (P = 0.07), though neither were statistically significant. Females with cleft lip and/or cleft palate from either racial group had no differences from the controls. The serum from 90 mothers of patients with cleft lip and/or cleft palate were reacted against their child's lymphocytes. Of these crossmatch tests, 12% were found to be positive. These preliminary results suggest that male patients with isolated cleft palate are worthy of further studies with respect of HLA associations.
测定了133例唇腭裂患者的HLA类型。患有单纯腭裂的白种人患者显示出与HLA可能存在关联。11名男性患者中有10名具有HLA - A2，而8名女性患者中只有1名具有该类型（P<0.005）。患有唇腭裂的白种男性HLA - Aw24频率略有增加（P = 0.07），患有唇裂和/或腭裂的墨西哥裔美国男性抗原HLA - A28有所增加（P = 0.07），尽管两者均无统计学意义。两个种族中患有唇裂和/或腭裂的女性与对照组没有差异。对90例唇裂和/或腭裂患者母亲的血清与她们孩子的淋巴细胞进行反应。在这些交叉配型试验中，发现12%呈阳性。这些初步结果表明，患有单纯腭裂的男性患者在HLA关联方面值得进一步研究。
