Mong Cindy, Garon Edward B, Fuller Clark, Mahtabifard Ali, Mirocha James, Mosenifar Zab, McKenna Robert
Division of Hematology Oncology, UCLA David Geffen School of Medicine, 200 UCLA Medical Plaza, Suite 420 Los Angeles, CA 90024 USA.
J Cardiothorac Surg. 2011 Feb 25;6:19. doi: 10.1186/1749-8090-6-19.
This study was designed to assess the prevalence of smoking at time of lung cancer diagnosis in a surgical patient cohort referred for cardiothoracic surgery.
Retrospective study of lung cancer patients (n = 626) referred to three cardiothoracic surgeons at a tertiary care medical center in Southern California from January 2006 to December 2008. Relationships among years of smoking cessation, smoking status, and tumor histology were analyzed with Chi-square tests.
Seventy-seven percent (482) had a smoking history while 11.3% (71) were current smokers. The length of smoking cessation to cancer diagnosis was <1 year for 56 (13.6%), 1-10 years for 110 (26.8%), 11-20 years for 87 (21.2%), 21-30 years for 66 (16.1%), 31-40 years for 44 (10.7%), 41-50 years for 40 (9.7%) and 51-60 years for 8 (1.9%). The mean cessation was 18.1 ± 15.7 years (n = 411 former smokers). Fifty-nine percent had stage 1 disease and 68.0% had adenocarcinoma. Squamous cell carcinoma was more prevalent in smokers (15.6% vs. 8.3%, p = 0.028); adenocarcinoma was more prevalent in never-smokers (79.9% versus 64.3%, p = 0.0004). The prevalence of adenocarcinoma varied inversely with pack year (p < 0.0001) and directly with years of smoking cessation (p = 0.0005).
In a surgical lung cancer cohort, the majority of patients were smoking abstinent greater than one decade before the diagnosis of lung cancer.
本研究旨在评估因心胸外科手术而转诊的外科手术患者队列中肺癌诊断时的吸烟率。
对2006年1月至2008年12月在南加州一家三级医疗中心就诊于三位心胸外科医生的肺癌患者（n = 626）进行回顾性研究。采用卡方检验分析戒烟年限、吸烟状况和肿瘤组织学之间的关系。
77%（482例）有吸烟史，11.3%（71例）为当前吸烟者。从戒烟到癌症诊断的时间<1年的有56例（13.6%），1 - 10年的有110例（26.8%），11 - 20年的有87例（21.2%），21 - 30年的有66例（16.1%），31 - 40年的有44例（10.7%），41 - 50年的有40例（9.7%），51 - 60年的有8例（1.9%）。平均戒烟时间为18.1±15.7年（n = 411例既往吸烟者）。59%为1期疾病，68.0%为腺癌。鳞状细胞癌在吸烟者中更常见（15.6%对8.3%，p = 0.028）；腺癌在从不吸烟者中更常见（79.9%对64.3%，p = 0.0004）。腺癌的患病率与吸烟包年数呈负相关（p < 0.0001），与戒烟年限呈正相关（p = 0.0005）。
在一个外科肺癌队列中，大多数患者在肺癌诊断前已戒烟超过十年。
