Departamento de Biologia, Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Avenida 24 A, 1515, 13506-900-Rio Claro, CP 199, SP, Brazil.
Exp Parasitol. 2011 Jun;128(2):151-8. doi: 10.1016/j.exppara.2011.02.003. Epub 2011 Feb 23.
Because of the medical and veterinary importance of ticks and the wide use of synthetic chemical substances such as permethrin (active ingredient of Advantage® Max3 - Bayer)for their control, this study evaluated the effects of different concentrations (206, 1031 and 2062 ppm) of the acaricide on the salivary glands of Rhipicephalus sanguineus semi-engorged females. Results showed that permethrin is a potent substance that acts morpho-physiologically in the tick glandular tissue, causing changes in the acini shape intense vacuolation in acinar cells, and disruption of the tissue by cell death process, with subsequent formation of apoptotic bodies, especially at higher concentrations, thus precluding the accurate identification of different types of acini. Importantly, it is demonstrated that permethrin acts on salivary gland tissue, as well as affecting the nervous system, accelerating the process of glandular degeneration, and interfering with the engorgement process of female ticks, preventing them from completing the feeding process.
由于蜱虫在医学和兽医方面的重要性，以及广泛使用拟除虫菊酯等合成化学物质（如除虫菊酯，Advantage® Max3 的有效成分-拜耳公司）来控制它们，本研究评估了不同浓度（206、1031 和 2062 ppm）的杀蜱剂对半饱吸血的雌性 Rhipicephalus sanguineus 唾液腺的影响。结果表明，除虫菊酯是一种有效物质，它在蜱虫的腺体组织中发挥形态生理学作用，导致腺泡形状发生变化，腺泡细胞出现强烈空泡化，并通过细胞死亡过程破坏组织，随后形成凋亡小体，尤其是在较高浓度下，从而无法准确识别不同类型的腺泡。重要的是，研究表明，除虫菊酯不仅作用于唾液腺组织，还会影响神经系统，加速腺体退化过程，并干扰雌性蜱虫的吸血过程，使它们无法完成吸血过程。
