Department of Medicine, Winthrop-University Hospital, 222 Station Plaza North, Mineola, NY 11501, USA.
Prog Lipid Res. 2011 Jul;50(3):213-24. doi: 10.1016/j.plipres.2011.02.001. Epub 2011 Feb 23.
Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality in the United States and in many other countries. Dysfunctional lipid homeostasis plays a central role in the initiation and progression of atherosclerotic lesions. The ATP-binding cassette (ABC) transporters are transmembrane proteins that hydrolyze ATP and use the energy to drive the transport of various molecules across cell membranes. Several ABC transporters play a pivotal role in lipid trafficking. They are critically involved in cholesterol and phospholipid efflux and reverse cholesterol transport (RCT), processes that maintain cellular cholesterol homeostasis and protect arteries from atherosclerosis. In this article we provide a review of the current literature on the biogenesis of ABC transporters and highlight their proposed functions in atheroprotection.
动脉粥样硬化性心血管疾病是美国和许多其他国家发病率和死亡率的主要原因。脂质稳态失调在动脉粥样硬化病变的发生和进展中起着核心作用。三磷酸腺苷结合盒（ABC）转运蛋白是一种跨膜蛋白，它可以水解三磷酸腺苷并利用能量将各种分子运输穿过细胞膜。几种 ABC 转运蛋白在脂质转运中起着关键作用。它们在胆固醇和磷脂外排以及胆固醇逆转运（RCT）中起着至关重要的作用，这些过程维持着细胞内胆固醇的稳态，并保护动脉免受动脉粥样硬化的侵害。本文综述了 ABC 转运蛋白生物发生的最新文献，并强调了它们在动脉粥样硬化保护中的潜在作用。
