Schmitz G, Kaminski W E
Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93042 Regensburg, Germany.
Front Biosci. 2001 Mar 1;6:D505-14. doi: 10.2741/schmitz.
ATP-binding cassette (ABC) proteins form a group of highly conserved cellular transmembrane transporters. Studies over the past year have implicated ABC transporters in cellular lipid trafficking processes. This notion has recently been confirmed and extended by the finding that the ABC transporter ABCA1 is a key regulator of high-density lipoprotein (HDL) metabolism and macrophage targeting to the RES or the vascular wall. Expression of a large number of ABC transporters in monocytes/macrophages and their regulation by cholesterol flux render these transporter molecules potentially critical players in chronic inflammatory diseases such as atherosclerosis.
ATP结合盒（ABC）蛋白构成了一组高度保守的细胞跨膜转运蛋白。过去一年的研究表明ABC转运蛋白参与细胞脂质转运过程。最近这一观点得到证实并有所扩展，因为发现ABC转运蛋白ABCA1是高密度脂蛋白（HDL）代谢以及巨噬细胞靶向网状内皮系统（RES）或血管壁的关键调节因子。大量ABC转运蛋白在单核细胞/巨噬细胞中的表达及其受胆固醇通量的调节，使这些转运蛋白分子可能成为动脉粥样硬化等慢性炎症性疾病的关键参与者。
