Schmitz G, Kaminski W E, Orsó E
Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany.
Curr Opin Lipidol. 2000 Oct;11(5):493-501. doi: 10.1097/00041433-200010000-00007.
ATP-binding cassette (ABC) transporters constitute a group of evolutionary highly conserved cellular transmembrane transport proteins. Recent work has implicated ABC transporters in cellular transmembrane lipid transport and hereditary diseases have been causatively linked to defective ABC transporters translocating lipid compounds. The emerging concept that a defined subset of ABC transporters is intimately involved in cellular lipid trafficking has recently been substantiated convincingly by the finding that ABCA1 plays a central role in the regulation of HDL metabolism and macrophage targeting to the RES or the vascular wall. Differentiation dependent expression of a large number of ABC transporters in monocytes/macrophages and their regulation by sterol flux render these transporter molecules potentially critical players in atherogenesis and other chronic inflammatory diseases.
ATP结合盒（ABC）转运蛋白构成了一组进化上高度保守的细胞跨膜转运蛋白。最近的研究表明，ABC转运蛋白参与细胞跨膜脂质转运，并且遗传性疾病与转运脂质化合物的ABC转运蛋白缺陷存在因果关系。最近发现ABCA1在高密度脂蛋白（HDL）代谢调节以及巨噬细胞靶向网状内皮系统（RES）或血管壁中起核心作用，这一发现令人信服地证实了一个新出现的概念，即特定亚组的ABC转运蛋白与细胞脂质转运密切相关。单核细胞/巨噬细胞中大量ABC转运蛋白的分化依赖性表达及其受甾醇通量的调节，使这些转运蛋白分子可能成为动脉粥样硬化和其他慢性炎症性疾病的关键参与者。
