Postgraduate Department of Biochemistry, Bharathi Women's College, Affiliated to University of Madras, Chennai 600108, Tamil Nadu, India.
Eur J Obstet Gynecol Reprod Biol. 2011 Jun;156(2):158-64. doi: 10.1016/j.ejogrb.2011.01.026. Epub 2011 Feb 25.
Pre-eclampsia is a hypertensive disorder characterized by maternal vascular endothelial dysfunction. It is likely that this enhanced rate of endothelial cell stress is associated with the pre- and post-partum complications of both mother and fetus. Deciphering the expression pattern of factors involved in altering placental endothelial cell viability in pre-eclampsia aids in identifying components that may protect the fetus from the consequences of placental dysfunction and oxidative stress.
Expression of thioredoxin (Trx), an antioxidant protein; heat shock protein (HSP) 70, a cytoprotective protein; heat shock factor (HSF)1, a transcriptional factor of HSPs; and apoptosis signal-regulating kinase 1 (ASK1), a pro-apoptotic protein, was elucidated in endothelial cells from human term placentas of normotensive and pre-eclamptic subjects (n=35).
A significant increase in HSP70 (p<0.05), HSF1 (p<0.05), Trx (p<0.05) and an insignificant increase in ASK1 were noted in pre-eclamptic endothelial cells.
This analysis supports the role of HSP70 expression in promoting cell survival by regulating ASK expression in pre-eclampsia.
子痫前期是一种以母体血管内皮功能障碍为特征的高血压疾病。这种增强的内皮细胞应激率很可能与母亲和胎儿的产前和产后并发症有关。解析与改变子痫前期胎盘内皮细胞活力相关的因子的表达模式有助于识别可能保护胎儿免受胎盘功能障碍和氧化应激后果的成分。
在正常血压和子痫前期患者（n=35）的人足月胎盘中，阐明了抗氧化蛋白硫氧还蛋白 (Trx)、细胞保护蛋白热休克蛋白 (HSP)70、HSP 的转录因子热休克因子 1 (HSF1) 和促凋亡蛋白凋亡信号调节激酶 1 (ASK1) 的表达。
子痫前期内皮细胞中 HSP70（p<0.05）、HSF1（p<0.05）、Trx（p<0.05）表达显著增加，ASK1 表达略有增加。
该分析支持 HSP70 表达通过调节子痫前期中的 ASK 表达来促进细胞存活的作用。
