Ophthalmology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Early Hum Dev. 2011 May;87(5):331-4. doi: 10.1016/j.earlhumdev.2011.01.042. Epub 2011 Feb 24.
Tobacco smoking during pregnancy alters neurodevelopment. Optical coherence tomography (OCT) provides precise measurements of the retinal nerve fiber layer (RNFL), which forms part of the central nervous system.
To assess using the OCT how smoking during pregnancy would affect optic nerve development as detected in human offspring.
Visual examination and OCT were performed on a group of children (n=70; 4.15-13.50 years of age), classified as being exposed or not to maternal smoking during gestational period. The association between smoking during pregnancy and RNFL thickness was assessed by a linear regression analysis adjusted for possible confounding factors.
Although visual outcomes did not differ between groups, a significant decrease in the RNFL thickness was found in the group of infants exposed to smoke (105.3 vs 95.6; p=0.002), even when adjusting for gestational age, birth weight or gender.
OCT measurements show that intrautero exposure to tobacco smoke interferes with the development of the optic nerve.
孕期吸烟会改变神经发育。光学相干断层扫描（OCT）可精确测量视网膜神经纤维层（RNFL），该层构成了中枢神经系统的一部分。
利用 OCT 评估孕期吸烟如何影响人胎儿的视神经发育。
对一组儿童（n=70；年龄 4.15-13.50 岁）进行视力检查和 OCT 检查，根据母亲在妊娠期是否吸烟将其分为暴露组或非暴露组。通过线性回归分析评估孕期吸烟与 RNFL 厚度之间的关联，并对可能的混杂因素进行调整。
尽管两组之间的视力结果没有差异，但暴露于烟雾的婴儿组的 RNFL 厚度明显变薄（105.3 比 95.6；p=0.002），即使在调整了胎龄、出生体重或性别后也是如此。
OCT 测量结果表明，宫内暴露于烟草烟雾会干扰视神经的发育。
