Okumura M, Amato Neto V, Campos R, da Silva A F, Moreira A A, de Souza H B, Pinto P L, Matsubara L
Laboratório de Investigação Médica-Parasitologia, Faculdade de Medicina, Universidade de São Paulo.
Rev Hosp Clin Fac Med Sao Paulo. 1990 Mar-Apr;45(2):53-6.
The relations between immunosuppression and human or experimental infection by Trypanosoma cruzi have recently been the subject of great interest, specially because of the wider use of drugs acting on immunity and of organ transplantation programs, now in frank expansion. The use of cyclosporin turned necessary to know adequately its interactions with T. cruzi parasitosis, and this has been the objective of the present study, regarding the acute phase in mice, in comparison to the use of prednisone. It was verified that cyclosporin, alone or associated to the corticosteroids, promotes and enhancement of the parasitosis, as shown by the assessment of parasitemia, the amount of amastigote forms in the heart and the severity of cardiac inflammation. Such observations may be useful in clinical practice, calling the attention for necessity of a strict control of such cases an eventually the use of an antiparasitic agent.
免疫抑制与克氏锥虫的人体感染或实验性感染之间的关系近来备受关注，特别是由于作用于免疫的药物使用更为广泛以及器官移植项目目前正在迅速扩张。使用环孢素就有必要充分了解其与克氏锥虫寄生虫病的相互作用，这就是本研究的目的，该研究针对小鼠急性期，与使用泼尼松进行比较。结果证实，单独使用环孢素或与皮质类固醇联合使用，都会促进寄生虫病的发展，这从对寄生虫血症的评估、心脏中无鞭毛体形式的数量以及心脏炎症的严重程度可以看出。这些观察结果在临床实践中可能有用，提醒人们注意对此类病例进行严格控制的必要性，并最终可能需要使用抗寄生虫药物。
