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[利用免疫抑制小鼠以尝试改进克氏锥虫感染的诊断]

[Use of immunosuppressed mice in an attempt to improve the diagnosis of infection by Trypanosoma cruzi].

作者信息

Miyamoto A, Campos R, Amato Neto V, de Souza H B, Matsubara L, Moreira A A

出版信息

Rev Hosp Clin Fac Med Sao Paulo. 1989 Jul-Aug;44(4):146-8.

PMID:2516360
Abstract

In order to demonstrate low level parasitemias of Trypanosoma cruzi, a procedure based on the pharmacologic development of immunosuppression and subsequente innoculation of a test blood specimen was evaluated in mice. Prednisone was effective for the procedure and my be considered for diagnosis and for clinical and laboratorial follow-up of patients with Chagas'disease, submitted to heart transplantation. However, prednisone effectiveness depended from the level of parasitemia.

摘要

为了检测克氏锥虫的低水平寄生虫血症,在小鼠中评估了一种基于免疫抑制药物开发及随后接种测试血样的程序。泼尼松对该程序有效,对于接受心脏移植的恰加斯病患者的诊断、临床和实验室随访可考虑使用。然而,泼尼松的有效性取决于寄生虫血症水平。

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[Use of immunosuppressed mice in an attempt to improve the diagnosis of infection by Trypanosoma cruzi].[利用免疫抑制小鼠以尝试改进克氏锥虫感染的诊断]
Rev Hosp Clin Fac Med Sao Paulo. 1989 Jul-Aug;44(4):146-8.
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