Kierszenbaum F, Gottlieb C A, Budzko D B
Tropenmed Parasitol. 1983 Mar;34(1):4-6.
Treatment with the immunoregulatory fungus metabolite cyclosporin A exacerbated the course of Trypanosoma cruzi infection in outbred as well as in inbred BALB/c mice. This effect was not observed in congenitally athymic, nu/nu, mice but was readily reproduced in their thymus-bearing, nu/+, littermates. These results suggest that the deleterious action of cyclosporin A on the course of experimental Chagas' disease results from activity of the drug on thymus or thymus-derived lymphocytes and emphasizes the role of T cells in host defense against T. cruzi infection.
用免疫调节真菌代谢产物环孢菌素A进行治疗会使远交系以及近交系BALB/c小鼠的克氏锥虫感染病程恶化。在先天性无胸腺的裸鼠（nu/nu）中未观察到这种效应，但在有胸腺的同窝裸鼠（nu/+）中很容易重现。这些结果表明，环孢菌素A对实验性恰加斯病病程的有害作用源于该药物对胸腺或胸腺来源淋巴细胞的活性，并强调了T细胞在宿主抵御克氏锥虫感染中的作用。
