Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, S-413 45 Gothenburg, Sweden.
Trends Endocrinol Metab. 2011 Apr;22(4):117-23. doi: 10.1016/j.tem.2011.01.002. Epub 2011 Feb 23.
The human gut is home to a vast number of bacteria, the microbiota, whose genomes complement our own set of genes. The gut microbiota functions at the intersection between host genotype and diet to modulate host physiology and metabolism, and recent data have revealed that the gut microbiota can affect obesity. The gut microbiota contributes to host metabolism by several mechanisms including increased energy harvest from the diet, modulation of lipid metabolism, altered endocrine function, and increased inflammatory tone. The gut microbiota could thus be considered to be an environmental factor that modulates obesity and other metabolic diseases.
人类肠道是大量细菌（微生物群）的家园，其基因组补充了我们自身基因的一套。肠道微生物群位于宿主基因型和饮食的交汇处，调节宿主的生理和代谢，最近的数据表明，肠道微生物群可以影响肥胖。肠道微生物群通过多种机制促进宿主代谢，包括从饮食中增加能量收获、调节脂质代谢、改变内分泌功能和增加炎症反应。因此，可以将肠道微生物群视为调节肥胖和其他代谢疾病的环境因素。
