Hermeto M V, Bicalho R S, de Melo A L, Pereira L H
Grupo Interdepartamental de Estudos Sobre Esquistossomose (GIDE), Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Rev Inst Med Trop Sao Paulo. 1990 May-Jun;32(3):168-71. doi: 10.1590/s0036-46651990000300004.
In the experimental schistosomiasis mansoni glucocorticoids cause a reduction in the worm burden when administered in the week of infection or, the longest, at the next week. In order to determinate the probable(s) site(s) of reduction of the worm burden, mice were infected with cercariae of LE strain of S. mansoni and dexamethasone was administered daily (50 mg/kg, subcutaneously) starting 1 hour before infection until the eighth day. Mice were sacrificed daily starting on the third day after infection until the ninth day, and schistosomula from lungs were collected. Six weeks after infection, the remaining mice were sacrificed and perfused for adult worm recovery. Analysis of the results showed that the non-treated mice presented larger numbers of lung larvae than the treated ones, and this difference was also found later in the worm burden in the portal system. This difference may reflect the early death of larvae in treated animals, before or after reaching the lungs.
在实验性曼氏血吸虫病中，糖皮质激素在感染当周或最长在下周给药时，可使虫负荷降低。为了确定虫负荷降低的可能部位，将小鼠感染曼氏血吸虫LE株尾蚴，并从感染前1小时开始每天（50毫克/千克，皮下注射）给予地塞米松，直至第8天。从感染后第3天开始每天处死小鼠，直至第9天，并收集肺部的童虫。感染6周后，处死其余小鼠并进行灌注以回收成虫。结果分析表明，未治疗的小鼠肺部幼虫数量比治疗组多，在门静脉系统的虫负荷中也发现了这种差异。这种差异可能反映了治疗动物中幼虫在到达肺部之前或之后的早期死亡。
