Hermeto M V, Bicalho R S, da Silva R E, de Melo A L, Pereira L H
Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Rev Inst Med Trop Sao Paulo. 1994 Mar-Apr;36(2):99-104. doi: 10.1590/s0036-46651994000200001.
Mice infected with about 90 cercariae of Schistosoma mansoni (LE strain) were treated during five consecutive days with dexamethasone (50 mg/Kg, subcutaneously), starting on the 42nd day of infection. Groups of five mice were then daily sacrificed from the first day after onset of treatment until the first day after. The perfusion of the portal system was performed and a piece of the intestine was processed for qualitative and quantitative oograms. This treatment carries to larger numbers of eggs in the tissues of treated mice, when compared with untreated groups. No changes were observed in the kinetics of oviposition, as all stages of viable eggs were observed in the tissues of treated and control mice. These data reinforce the hypothesis of a partial blockade of the egg excretion in immunosuppressed mice.
感染约90条曼氏血吸虫（LE株）尾蚴的小鼠，从感染后第42天开始，连续5天皮下注射地塞米松（50毫克/千克）进行治疗。然后从治疗开始后的第一天到之后的第一天，每天处死5只小鼠组成的小组。进行门静脉系统灌注，并取一段肠道进行定性和定量虫卵图谱分析。与未治疗组相比，这种治疗使治疗小鼠组织中的虫卵数量更多。在产卵动力学方面未观察到变化，因为在治疗小鼠和对照小鼠的组织中都观察到了所有存活阶段的虫卵。这些数据支持了免疫抑制小鼠中虫卵排泄存在部分阻断的假说。
