Department of Medicine/Unit of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland.
FEBS Lett. 2011 May 20;585(10):1384-92. doi: 10.1016/j.febslet.2011.02.027. Epub 2011 Feb 25.
The house mouse Mus musculus represents a valuable tool for the analysis and the understanding of the mammalian circadian oscillator. Forward and reverse genetics allowed the identification of clock components and the verification of their function within the circadian clockwork. In many cases unforeseen links were discovered between a particular circadian regulatory protein and various diseases or syndromes. Thus, this model system is not only perfectly suited to pinpoint the components of the mammalian circadian clock, but also to unravel metabolic, physiological, and pathological processes linked to the circadian timing system.
家鼠（Mus musculus）是分析和理解哺乳动物生物钟振荡器的重要工具。正向和反向遗传学允许鉴定时钟组件，并验证它们在生物钟中的功能。在许多情况下，人们发现特定的生物钟调节蛋白与各种疾病或综合征之间存在意想不到的联系。因此，这个模型系统不仅非常适合确定哺乳动物生物钟的组成部分，而且还可以揭示与昼夜节律计时系统相关的代谢、生理和病理过程。
