Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing 100730, China.
Biomolecules. 2024 Jul 4;14(7):796. doi: 10.3390/biom14070796.
Circadian rhythms are a ubiquitous feature throughout the organism. Accumulating evidence suggests that the dysfunction of circadian rhythms due to genetic mutations or environmental factors contributes to the genesis and progress of multiple diseases. The physiological homeostasis of the ocular surface, like any other tissue or organ, is also orchestrated by circadian rhythms. In this review, we summarize the molecular clocks and the expression of clock-controlled genes in the mammalian ocular surface. Based on the circadian expression of these genes, we conclude the diurnal oscillations of cellular biological activities in the mammalian ocular surface. Moreover, we evaluate the factors entraining circadian oscillators in the ocular surface. Finally, we further discuss the latest development of the close correlation between circadian rhythms and ocular health. Briefly, this review aimed to synthesize the previous studies to aid in understanding the importance of circadian rhythms in the ocular surface and the possible opportunities for circadian rhythm-based interventional strategies to restore the homeostasis of the ocular surface.
昼夜节律是生物体内普遍存在的特征。越来越多的证据表明，由于基因突变或环境因素导致的昼夜节律失调，可能会导致多种疾病的发生和发展。与任何其他组织或器官一样，眼球表面的生理稳态也受昼夜节律的调控。在这篇综述中，我们总结了哺乳动物眼球表面的分子钟和时钟控制基因的表达。基于这些基因的昼夜表达，我们得出了哺乳动物眼球表面细胞生物活动的昼夜波动结论。此外，我们评估了眼球表面昼夜节律钟的同步因子。最后，我们进一步讨论了昼夜节律与眼部健康之间密切关联的最新进展。简而言之，本篇综述旨在综合之前的研究，以帮助理解昼夜节律在眼球表面的重要性，以及基于昼夜节律的干预策略恢复眼球表面稳态的可能机会。
