Department of Morphological and Biomedical Sciences, Section of Anatomy and Histology, University of Verona, Italy.
Physiol Behav. 2011 May 3;103(2):134-43. doi: 10.1016/j.physbeh.2011.02.026. Epub 2011 Feb 25.
Altered perceptual and emotional processing might bind impaired cognitive mechanisms during aging; however the nature of these sensory perception modifications is still unknown. In the present experiment we analyzed in rats, from early to mature life (2 to 11 months old), the response to unattended auditory evoked stimulation (Auditory evoked potential, AEP) and the power spectrum of spontaneous electroencephalogram (EEG), with the aim of unraveling the onset and target functional effects of aging. Somatosensory and cingulate cortex, mediodorsal thalamus and CA3 hippocampus were chosen for examination based on their involvement in sensory processing and age-related deficits. The main finding of this study is the early onset of age-related changes in adult rats as can be established with both AEP's and frequency analyses, and its diversity between brain regions during normal aging.
感知和情绪处理的改变可能会在衰老过程中结合受损的认知机制；然而，这些感官知觉改变的性质仍不清楚。在本实验中，我们分析了从早期到成熟阶段（2 至 11 个月大）的大鼠对未注意听觉诱发刺激（听觉诱发电位，AEP）的反应和自发脑电图（EEG）的功率谱，旨在揭示衰老的起始和目标功能效应。体感和扣带皮层、中脑背侧丘脑和 CA3 海马体被选择用于检查，因为它们参与了感觉处理和与年龄相关的缺陷。本研究的主要发现是成年大鼠的与年龄相关的变化在早期就出现了，这可以通过 AEP 和频率分析来确定，并且在正常衰老过程中，不同脑区之间的变化也不同。
