Cadiergues Marie-Christine, Bonneau Stéphane G, Fourier Josephus J
Ecole Nationale Vétérinaire de Toulouse 23, chemin des Capelles, 31076 Toulouse cedex 3, France.
J Feline Med Surg. 2011 Apr;13(4):304-8. doi: 10.1016/j.jfms.2011.01.004. Epub 2011 Feb 26.
A new fipronil-based spot-on formulation was evaluated against experimental flea infestations in cats in two studies. In both studies, eight cats served as negative controls (groups 1 and 4); on day 0, eight cats were treated with a 10% w/v fipronil-based spot-on solution (Effipro Spot-on, 0.5ml per cat, groups 2 and 5) and eight cats served as positive controls (Frontline Spot-on, 0.5ml per cat, groups 3 and 6). Each cat was infested on day - 1 with 50 fleas (study 1) and weekly (day 7-day 56) with 100 fleas (study 2). Geometric mean flea counts obtained 48h after the treatment or each re-infestation were reduced by 99.0 and 98.3% in groups 2 and 3, respectively, on day 2, compared to the negative control group. Cats were protected from re-infestations with an efficacy >99% for 58 days in group 5 and for 37 days in group 6.
在两项研究中，对一种新的基于氟虫腈的滴剂配方进行了评估，以对抗猫身上的实验性跳蚤感染。在两项研究中，八只猫作为阴性对照（第1组和第4组）；在第0天，八只猫用10% w/v的基于氟虫腈的滴剂溶液（Effipro滴剂，每只猫0.5毫升，第2组和第5组）进行治疗，八只猫作为阳性对照（福来恩滴剂，每只猫0.5毫升，第3组和第6组）。每只猫在第-1天感染50只跳蚤（研究1），并在第7天至第56天每周感染100只跳蚤（研究2）。与阴性对照组相比，在第2天，第2组和第3组在每次治疗或再次感染后48小时获得的几何平均跳蚤计数分别减少了99.0%和98.3%。第5组的猫在58天内对再次感染的保护效果>99%，第6组为37天。
