Department of Neurology and Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
Epilepsy Behav. 2011 Mar;20(3):528-32. doi: 10.1016/j.yebeh.2011.01.010. Epub 2011 Feb 26.
The quality of life (QOL) of individuals with well-controlled epilepsy (WCE) is often not considered. We therefore investigated predictors determining QOL in patients who had been seizure free at least 1 year on stable antiepileptic drug (AED) monotherapy. They were asked to complete self-report health questionnaires, including the Beck Depression Inventory (BDI), Adverse Event Profile (AEP), and Quality of Life in Epilepsy Inventory-31 (QOLIE-31). We looked for predictors of QOLIE-31 scores among the various demographic, socioeconomic, and clinical factors and BDI, and AEP scores. Depression symptoms were manifested by 18.7% of patients. People with depression symptoms were more likely to report adverse events than those without depression symptoms. The strongest predictor of QOL was BDI score, followed by AEP total score, years of education, and income. BDI score had 3.37 times the effect of AEP total score. In conclusion, QOL of patients with WCE is determined mainly by depressive symptoms.
个体的生活质量（QOL）往往不被关注，尤其是那些癫痫控制良好（WCE）且至少已接受稳定抗癫痫药物（AED）单药治疗 1 年以上无发作的患者。我们调查了能确定这些患者 QOL 的预测因素，他们完成了自我报告的健康问卷，包括贝克抑郁量表（BDI）、不良反应概况（AEP）和癫痫患者生活质量量表-31 项（QOLIE-31）。我们在各种人口统计学、社会经济学和临床因素以及 BDI 和 AEP 评分中寻找 QOLIE-31 评分的预测因素。18.7%的患者表现出抑郁症状。有抑郁症状的人比没有抑郁症状的人更容易报告不良反应。生活质量的最强预测因素是 BDI 评分，其次是 AEP 总分、受教育年限和收入。BDI 评分对 AEP 总分的影响是其 3.37 倍。总之，WCE 患者的生活质量主要取决于抑郁症状。
