Santiago Piedad, Berrio María, Olmedo Pablo, Velasco Inés, Sánchez Baltasar, García Eduardo, Martínez Julia, Soriguer Federico
UGC de Análisis Clínicos y Servicio de Radiología, Complejo Hospitalario de Jaén, Jaén, España.
Endocrinol Nutr. 2011 Feb;58(2):62-7. doi: 10.1016/j.endonu.2010.12.004. Epub 2011 Feb 26.
To evaluate thyroid function in the three trimesters of pregnancy in healthy women taking iodine and to define the reference ranges of normality in this population.
Descriptive study of pregnant women to define the ranges of normality of thyroid hormones in this population.
Jaen and Osuna (Spain).
Healthy pregnant women.
Thyroid hormone determination in the three trimesters of pregnancy in healthy women taking iodine supplements.
A total of 429 pregnant women taking iodine supplements to maintain urinary iodine levels within the normal range were included. T4-l levels were between 0.60 and 1.06 in the first trimester, between 0.43 and 0.85 ng/dl in the second and between 0.40 and 0.82 ng/dl in the third. Thyroid stimulating hormone (TSH) reference values were between 0.23 and 4.18μUI/ml in the first trimester, 1.78 and 3.89μUI/ml in the second and 2.01 and 4.30μUI/ml in the third. T3-l values were between 2.33 and 3.84 pg/ml in the first trimester, between 2.04 and 3.51 pg/ml in the second and between 1.99 and 3.46 pg/ml in the third.
Bearing the 3rd and 97th percentiles in mind, the reference ranges in our population were far below those recommended by our reference laboratory. In view of these results, these values should be redefined to avoid incorrect diagnoses of hyperthyroxinemia in healthy pregnant women.
评估服用碘的健康孕妇孕期三个阶段的甲状腺功能，并确定该人群的正常参考范围。
对孕妇进行描述性研究，以确定该人群甲状腺激素的正常范围。
西班牙哈恩和奥苏纳。
健康孕妇。
对服用碘补充剂的健康孕妇孕期三个阶段的甲状腺激素进行测定。
共纳入429名服用碘补充剂以维持尿碘水平在正常范围内的孕妇。孕早期T4-l水平在0.60至1.06之间，孕中期在0.43至0.85 ng/dl之间，孕晚期在0.40至0.82 ng/dl之间。促甲状腺激素（TSH）参考值孕早期在0.23至4.18μUI/ml之间，孕中期在1.78至3.89μUI/ml之间，孕晚期在2.01至4.30μUI/ml之间。孕早期T3-l值在2.33至3.84 pg/ml之间，孕中期在2.04至3.51 pg/ml之间，孕晚期在1.99至3.46 pg/ml之间。
考虑到第3百分位数和第97百分位数，我们人群的参考范围远低于我们参考实验室推荐的范围。鉴于这些结果，应重新定义这些值，以避免对健康孕妇进行甲状腺素血症的错误诊断。
