Service de pathologie digestive, HIA Laveran, BP 60149, 13384 Marseille cedex 13, France.
Clin Res Hepatol Gastroenterol. 2011 May;35(5):418-9. doi: 10.1016/j.clinre.2011.01.010. Epub 2011 Feb 26.
Glandular heterotopia of the upper esophagus is a congenital abnormality that is frequently discovered during upper digestive tract endoscopy (in 0.26-4.9% of cases), but usually with no malignant potential. Indeed, adenocarcinoma of the upper esophagus related to such lesions is a rare entity. We report here the 27th observation of this rare type of tumor in an 87-year-old man complaining of cervical dysphagia. This adenocarcinoma had developed from an area of gastric heterotopia 3 cm below the upper sphincter of the esophagus. The treatment regimen was based on exclusive radiochemotherapy, which led to a complete endoscopic response at the end of treatment. The patient's symptom-free survival was six months and overall survival was 17 months from diagnosis. This case of a rare tumor of the upper esophagus raises the question of whether the detection and surveillance of this type of heterotopia would be useful and, thus, to be recommended.
食管上段的腺体异位是一种先天性异常，在上消化道内镜检查中经常被发现（占 0.26-4.9%的病例），但通常没有恶性潜能。事实上，与这种病变相关的食管上段腺癌是一种罕见的实体。我们在此报告了一例 87 岁男性患者的罕见肿瘤病例，该患者因颈部吞咽困难而就诊。该腺癌起源于食管上括约肌下方 3 厘米处的胃异位区。治疗方案基于单纯放化疗，治疗结束时内镜下完全缓解。患者无疾病生存时间为 6 个月，总生存时间为诊断后 17 个月。该例食管上段罕见肿瘤提出了一个问题，即这种异位的检测和监测是否有用，因此是否值得推荐。
