RUNX3蛋白在肝癌中的表达及其临床病理意义

[Expression of RUNX3 protein in hepatic cell carcinoma and its clinicopathological implications].

作者信息

Lu Yan-hui, Zheng Rui-dan, Chen Jie, Chen Bi-fen, Li Jian-guo, Lin Zhi-chuan

机构信息

Center of Hepatitis Treatment, 175 Hospital of PLA, Zhangzhou 363000, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2011 Feb;31(2):329-32.

PMID:21354923

Abstract

OBJECTIVE

To investigate the expression of RUNX3 protein in hepatic cell carcinoma (HCC) and its relationship with the clinicopathological factors of HCC.

METHODS

Immunohistochemistry was performed to detect the expression of RUNX3 protein in HCC and the surrounding normal tissues, and the relation of RUNX3 with the clinicopathological factors of HCC was analyzed.

RESULTS

The positivity rate of RUNX3 protein expression was 49.02% (25/51) in HCC tissues, significantly lower than that in the surrounding normal tissues [82.35% (42/51), Χ(2)=12.5706, P<0.01). RUNX3 protein expression varied significantly with such pathological factors as the differentiation degree, cancer-associated thrombosis in the portal vein and intrahepatic metastasis (P<0.05), but not with tumor diameter, location, tumoral hemorrhage, necrosis or histotypes of the tumor (P>0.05).

CONCLUSION

RUNX3 protein expression is lowered in HCC as compared with that in the surrounding normal tissue, suggesting an important role of RUNX3 in the tumorigenesis and development of HCC and the possible identity of RUNX3 gene as an anti-oncogene of HCC.

摘要

目的

探讨RUNX3蛋白在肝细胞癌（HCC）中的表达及其与HCC临床病理因素的关系。

方法

采用免疫组织化学法检测RUNX3蛋白在HCC组织及其周围正常组织中的表达，并分析RUNX3与HCC临床病理因素的关系。

结果

RUNX3蛋白在HCC组织中的阳性表达率为49.02%（25/51），显著低于其在周围正常组织中的表达率[82.35%（42/51），χ²=12.5706，P<0.01]。RUNX3蛋白表达随分化程度、门静脉癌栓及肝内转移等病理因素的变化而有显著差异（P<0.05），但与肿瘤直径、位置、肿瘤出血、坏死或组织学类型无关（P>0.05）。