Kosano H, Takatani O
Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
J Lipid Mediat. 1990 Mar-Apr;2(2):117-21.
The effect of ET-18-OCH3 on transferrin (Tf) binding in human breast cancer cell lines, MCF-7, ZR-75-1 and BT-20, and mouse fibroblast, Balb/c 3T3, was investigated. Pretreatment with 3-25 micrograms/ml ET-18-OCH3 increased the Tf binding at 37 degrees C and 4 degrees C in all cell lines tested. In MCF-7, both the affinity and the number of Tf binding sites were increased by ET-18-OCH3. These observations are of interest with respect to the action of ET-18-OCH3 on cell surface receptors.
研究了ET-18-OCH3对人乳腺癌细胞系MCF-7、ZR-75-1和BT-20以及小鼠成纤维细胞Balb/c 3T3中转铁蛋白（Tf）结合的影响。用3-25微克/毫升的ET-18-OCH3预处理可增加所有测试细胞系在37℃和4℃时的Tf结合。在MCF-7中，ET-18-OCH3增加了Tf结合位点的亲和力和数量。这些观察结果对于ET-18-OCH3对细胞表面受体的作用具有重要意义。
