Center for Neural Repair, Department of Neurosciences 0626, University of California, San Diego, La Jolla, California 92093, USA.
Nat Rev Drug Discov. 2011 Mar;10(3):209-19. doi: 10.1038/nrd3366.
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are actively produced and trafficked in multiple regions in the adult brain, where they influence neuronal activity, function and survival throughout life. The diverse presence and activity of BDNF suggests a potential role for this molecule in the pathogenesis and treatment of both neurological and psychiatric disorders. This article reviews the current understanding and future directions in BDNF-related research in the central nervous system, with an emphasis on the possible therapeutic application of BDNF in modifying fundamental processes underlying neural disease.
生长因子脑源性神经营养因子（BDNF）及其受体原肌球蛋白相关激酶受体 B 型（TRKB）在成年人大脑中的多个区域中被积极地产生和运输，在那里它们影响神经元的活动、功能和存活。BDNF 的多样性存在和活性表明该分子在神经和精神疾病的发病机制和治疗中可能具有潜在的作用。本文综述了中枢神经系统中与 BDNF 相关的研究的最新进展和未来方向，重点介绍了 BDNF 在改变神经疾病基础过程中的潜在治疗应用。
