[The role of cholecystokinin in the regulation of intestinal blood circulation and metabolism].

These studies were conducted to assess whether cholecystokinin (CCK) play a role in the regulation of intestinal blood flow and metabolic activity. Anesthetized dogs were subjected to laparotomy and implantation of transducers to measured intestinal blood flow (MBF), intestinal oxygen extraction (AVO2) and intraluminal pressure (IP). Intestinal oxygen consumption (VO2) was calculated as the product of the AVO2 and MBF. CCK8 infused intraarterially in doses 12.5, 25, 50, 75 and 100 pmol/kg-h increased significantly MBF by 5, 8, 11, 15 and 19%. IP increased significantly with the last three doses of CCK by 55, 87 and 145%, respectively. Glucose and oleic acid increased MBF by 12 and 37% and VO2 by 26 and 17%, respectively. Pretreatment with a highly selective CCK-receptor antagonist L-364 718 (1 mg/kg i.v.) abolished the vascular and motor responses to exogenous CCK and significantly reduced intestinal hyperemia and increase in VO2 in response to luminal oleic acid but not glucose. These findings indicate that endogenous CCK may play a role in the intestinal hyperemia after fatty meal and that this effect is primarily mediated by the CCK receptors.