α肾上腺素受体在刺激卵巢上神经引起的血管和雌二醇分泌反应中的作用。
The role of alpha adrenoceptors in the vascular and estradiol secretory responses to stimulation of the superior ovarian nerve.
机构信息
Department of Autonomic Neuroscience, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
出版信息
J Physiol Sci. 2011 May;61(3):247-51. doi: 10.1007/s12576-011-0135-1. Epub 2011 Feb 27.
Abstract
Electrical stimulation of the superior ovarian nerve in rats reduces both the plasma flow rate of ovarian venous blood (ovarian blood flow) and the ovarian estradiol secretion rate. Here, we examined the possible roles of alpha-adrenoceptors in these processes. The reduction of the plasma flow rate was blocked by an alpha 1- (prazosin), but not by an alpha 2- (yohimbine) adrenoceptor blocker. In contrast, the reduction of the estradiol secretion rate was blocked by yohimbine but not by prazosin. We conclude that ovarian vascular and estradiol secretory responses to superior ovarian nerve activation are mediated by alpha 1- and alpha 2-adrenoceptors, respectively.
摘要
电刺激大鼠的卵巢上神经可降低卵巢静脉血液（卵巢血流）的血浆流量和卵巢雌二醇分泌率。在这里，我们研究了 α-肾上腺素能受体在这些过程中的可能作用。α1-（哌唑嗪）而非 α2-（育亨宾）肾上腺素能受体阻滞剂可阻断血浆流量的减少。相比之下，雌二醇分泌率的降低可被育亨宾阻断，但不能被哌唑嗪阻断。我们得出结论，卵巢血管和雌二醇分泌对卵巢上神经激活的反应分别由 α1-和 α2-肾上腺素能受体介导。
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