帕金森病患者经十二指肠给予左旋多巴/卡比多巴凝胶治疗后同型半胱氨酸水平升高。
Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel.
机构信息
Department of Neurology, St. Joseph Hospital, Berlin-Weissensee, Gartenstr. 1, 13088, Berlin, Germany.
出版信息
J Neural Transm (Vienna). 2011 Sep;118(9):1329-33. doi: 10.1007/s00702-011-0614-9. Epub 2011 Feb 27.
Levodopa/carbidopa (LD/CD) application elevates total plasma homocysteine (thcys). We determined thcys-, LD- and 3-O-methyldopa (3-OMD) concentrations in 28 patients with Parkinson's disease (PD) on a LD/CD duodenal gel treatment. We found a distinct thcys increase (29.52 ± 28.98 μmol/l [median ± SD]) above the 15 μmol/l threshold and a significant (R = 0.7) correlation between LD and 3-OMD. thcys ascent was observed in relation with the onset of atherosclerosis, non-motor symptoms and polyneuropathy in PD patients in the long term.
左旋多巴/卡比多巴（LD/CD）的应用会提高总血浆同型半胱氨酸（thcys）水平。我们在 28 名接受 LD/CD 十二指肠凝胶治疗的帕金森病（PD）患者中测定了同型半胱氨酸（thcys）、LD 和 3-O-甲基多巴（3-OMD）的浓度。我们发现同型半胱氨酸水平明显升高（29.52 ± 28.98 μmol/l [中位数 ± 标准差]），超过了 15 μmol/l 的阈值，且 LD 和 3-OMD 之间存在显著相关性（R = 0.7）。在长期随访中，PD 患者的同型半胱氨酸水平升高与动脉粥样硬化、非运动症状和多发性神经病的发生有关。
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