The Mind Research Network, Albuquerque, New Mexico 87106, USA.
Magn Reson Med. 2011 Aug;66(2):324-32. doi: 10.1002/mrm.22858. Epub 2011 Feb 28.
A 1H magnetic resonance spectroscopic imaging study at 3T and short echo time was conducted to evaluate both the reproducibility, as measured by the interscan coefficient of variation (CV), and test-retest reliability, as measured by the intraclass correlation coefficient (ICC), of measurements of glutamate (Glu), combined glutamate and glutamine (Glx), myo-inositol (mI), N-acetylaspartate, creatine, and choline in 21 healthy subjects. The effect of partial volume correction on these measures and the relationship of reproducibility and reliability to data quality were also examined. A 1H magnetic resonance spectroscopic imaging slice was prescribed above the lateral ventricles and single repeat scans were performed within 30 min to minimize physiologic variability. Interscan CVs based on all the voxels varied from 0.05 to 0.07 for N-acetylaspartate, creatine, and choline to 0.10-0.13 for mI, Glu, and Glx. Findings on the reproducibility of gray and white matter estimates of N-acetylaspartate, creatine, and choline are consistent with previous studies using longer echo times, with CVs in the range of 0.02-0.04 and ICC in the range of 0.65-0.90. CVs for Glu, Glx, and mI are much lower than reported in previous studies at 1.5 T, while white matter mI (CV=0.04, ICC=0.93) and gray matter Glx (CV=0.04, ICC=0.68) demonstrated both high reproducibility and test-retest reliability.
一项在 3T 短回波时间下进行的 1H 磁共振波谱成像研究，旨在评估谷氨酸（Glu）、谷氨酸和谷氨酰胺（Glx）、肌醇（mI）、N-乙酰天冬氨酸、肌酸和胆碱的测量值的重复性（通过扫描间变异系数[CV]来衡量）和测试-重测可靠性（通过组内相关系数[ICC]来衡量）。还检查了部分体积校正对这些测量值的影响，以及重复性和可靠性与数据质量的关系。在侧脑室上方规定了 1H 磁共振波谱成像切片，并在 30 分钟内进行单次重复扫描，以最大程度地减少生理变异性。基于所有体素的 N-乙酰天冬氨酸、肌酸和胆碱的扫描间 CV 从 0.05 到 0.07 不等，mI、Glu 和 Glx 的 CV 从 0.10 到 0.13 不等。关于 N-乙酰天冬氨酸、肌酸和胆碱的灰质和白质估计值重复性的研究结果与以前使用更长回波时间的研究一致，CV 在 0.02-0.04 范围内，ICC 在 0.65-0.90 范围内。Glu、Glx 和 mI 的 CV 远低于以前在 1.5T 下的研究报告，而白质 mI（CV=0.04，ICC=0.93）和灰质 Glx（CV=0.04，ICC=0.68）则表现出较高的重复性和测试-重测可靠性。
