Zeng Ping, Peng Ming-Li, Xu Yi
Chemistry and Chemical Engineering College, Chongqing University, Chongqing 400030, China.
Yao Xue Xue Bao. 2010 Nov;45(11):1346-53.
Biodegradable nano/microparticles of poly(D, L-lactide-co-glycolide) (PLGA) is a novel non-viral gene vector, which has many advantages, such as safety, non-immunogenicity, easy of large-scale preparation and well load-capability. Therefore, more and more attentions and researches have been paid on its application. Especially, PLGA has shown enormous potential application value and space in the field of plasmid DNA (pDNA) delivery system. On the basis of the current situation of PLGA nano/microparticles for pDNA delivery, this paper focused on summarizing the current preparation approaches and surface modified methods of PLGA particle, furthermore showing its application in gene therapy and genetic vaccine delivery. These showed that PLGA nano/microparticles have extensive prospect in the development of controlled gene delivery system.
聚（D，L-丙交酯-共-乙交酯）（PLGA）的可生物降解纳米/微粒是一种新型非病毒基因载体，具有许多优点，如安全性高、无免疫原性、易于大规模制备且负载能力良好。因此，其应用受到了越来越多的关注和研究。特别是，PLGA在质粒DNA（pDNA）递送系统领域已显示出巨大的潜在应用价值和空间。基于PLGA纳米/微粒用于pDNA递送的现状，本文着重总结了PLGA微粒的当前制备方法和表面修饰方法，此外还展示了其在基因治疗和基因疫苗递送中的应用。这些表明PLGA纳米/微粒在可控基因递送系统的开发中具有广阔前景。
