Zhang Si-yun, Song Min, Lu Jun-Gang, Hang Tai-Jun
Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 210009, China.
Yao Xue Xue Bao. 2010 Nov;45(11):1433-9.
After oral administration of Salvia miltiorrhiza (Danshen in Chinese), Panax notoginseng (Sanqi in Chinese) and Danshen Sanqi combination suspensions to Beagle dogs, the plasma concentration-time profiles of danshensu, tanshinone II(A), cryptotanshinone, notoginsenoside R1, ginsenoside Rg1 and Rb1 were analyzed by LC-MS/MS. Pharmacokinetic parameters were calculated and analyzed with BAPP 2.0 software. The results showed that the Cmax and AUC of danshensu, notoginsenoside R1, ginsenoside Rg1 and Rb1 in Danshen Sanqi combination group all decreased in comparison with those of Danshen or Sanqi given alone, while the CLz/F and Vz/F increased to some extent. No significant differences of the pharmacokinetics of tanshinone II(A) and cryptotanshinone were observed between groups.
将丹参、三七及丹参三七复方混悬液经口给予比格犬后，采用液相色谱-串联质谱法（LC-MS/MS）分析丹酚酸B、丹参酮IIA、隐丹参酮、三七皂苷R1、人参皂苷Rg1和Rb1的血浆浓度-时间曲线。使用BAPP 2.0软件计算并分析药代动力学参数。结果表明，与单独给予丹参或三七相比，丹参三七复方组中丹酚酸B、三七皂苷R1、人参皂苷Rg1和Rb1的Cmax和AUC均降低，而CLz/F和Vz/F有一定程度升高。各给药组间丹参酮IIA和隐丹参酮的药代动力学参数无显著差异。
