Ma Fu-Wen, Jin Yong, Zhang Wen-Fang, Zhou Shao-Bing, Ni Cai-Hua
School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Yao Xue Xue Bao. 2010 Nov;45(11):1447-51.
Inorganic/polymer hybrid star polylactic acid (POSS-PLA) was obtained through ring-opening polymerization of lactide by using polyhydroxyl cage silsesquioxane (POSS-OH) as the core and tin (II) octoate as the catalyst. The star polylactic acid (POSS-PLA) was used to modify sodium alginate hydrophobically and a drug carrier was obtained. The drug release behavior was investigated by using ibuprofen as the model drug. The results showed that the drug loading rate could be improved and the release rate was postponed with an increase of POSS-PLA content in the carries. The release mechanism gradually changed from the first-order to the zero-order pattern after the modification.
以多羟基笼型倍半硅氧烷（POSS-OH）为核、辛酸亚锡为催化剂，通过丙交酯的开环聚合反应制备了无机/聚合物杂化星形聚乳酸（POSS-PLA）。用星形聚乳酸（POSS-PLA）对海藻酸钠进行疏水改性，得到一种药物载体。以布洛芬为模型药物研究了其释药行为。结果表明，随着载体中POSS-PLA含量的增加，载药量提高，释放速率延缓。改性后释放机制逐渐由一级模式转变为零级模式。
