School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450052, China.
Int J Biol Macromol. 2012 Apr 1;50(3):747-53. doi: 10.1016/j.ijbiomac.2011.12.003. Epub 2011 Dec 17.
Hydrophobically modified biomineralized polysaccharide alginate membrane with smart drug release property using sodium palmitate as the hydrophobic component was prepared via a one-step method. The formation of CaHPO(4) in the membrane was clearly identified through scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDS), X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy. Indomethacin release profiles of the modified alginate membrane were found to be pH- and thermo-responsive. The drug release of modified alginate membrane was around 60% within 12 h, while that of the alginate membrane was higher than 90%. These results indicate that the hydrophobic and biomineralized polysaccharide components can hinder the permeation of the encapsulated drug and reduce the drug release effectively. The resulting membrane can be used as "smart" materials for sustained dual-responsive drug delivery.
采用一步法制备了以棕榈酸钠为疏水分子的具有智能药物释放性能的疏水改性生物矿化多糖海藻酸盐膜。通过扫描电子显微镜（SEM）、能谱仪（EDS）、X 射线衍射（XRD）和傅里叶变换红外光谱（FT-IR）清楚地鉴定了膜中 CaHPO4 的形成。改性海藻酸盐膜的吲哚美辛释放曲线表现出 pH 和温度响应性。改性海藻酸盐膜在 12 小时内的药物释放量约为 60%，而海藻酸盐膜的药物释放量高于 90%。这些结果表明，疏水和生物矿化多糖成分可以阻碍包封药物的渗透，从而有效减少药物释放。所得膜可用作持续双重响应药物输送的“智能”材料。
