Department of Public Health, Southeast, Nanjing 210096, China.
J Biomed Nanotechnol. 2010 Dec;6(6):725-8. doi: 10.1166/jbn.2010.1135.
Chitosan (CS)/polylactic acid (PLA)/tripolyphotspate (TPP) nanosized microcapsules were prepared by emulsion-evaporation. The average diameter of the obtained nanosized microcapsules was around 100-300 nm, and a homogeneous size distribution and good dispersion were observed. The entrapment efficiency of the nanosized CS/PLA/TPP microcapsules for rapamycin was increased with the increase in amount of PLA. When the ratio of CS to PLA was 80 to 20, the entrapment efficiency of CS/PLA/TPP nanosized microcapsules for rapamycin reached the highest (89.8 +/- 1.72%). It was also observed that The RAPA entrapment efficiency reached its highest at 20% of addition dosage of RAPA.
壳聚糖（CS）/聚乳酸（PLA）/三聚磷酸钠（TPP）纳米级微胶囊通过乳液蒸发法制备。所得纳米级微胶囊的平均直径约为 100-300nm，观察到粒径分布均匀，分散性良好。载药纳米 CS/PLA/TPP 微胶囊对雷帕霉素的包封率随着 PLA 用量的增加而增加。当 CS 与 PLA 的比例为 80 比 20 时，CS/PLA/TPP 纳米级微胶囊对雷帕霉素的包封率达到最高（89.8±1.72%）。还观察到，当添加的 RAPA 用量为 20%时，RAPA 的包封效率达到最高。
