Department of Bioengineering, University of California, Berkeley, California 94720, USA.
ACS Nano. 2011 Apr 26;5(4):2824-30. doi: 10.1021/nn103324p. Epub 2011 Mar 1.
Miniaturized smart sensors that can perform sensitive and selective real-time monitoring of target analytes are tremendously valuable for various sensing applications. We developed selective nanocoatings by combining trinitrotoluene (TNT) receptors bound to conjugated polydiacetylene (PDA) polymers with single-walled carbon nanotube field-effect transistors (SWNT-FET). Selective binding events between the TNT molecules and phage display derived TNT receptors were effectively transduced to sensitive SWNT-FET conductance sensors through the PDA coating layers. The resulting sensors exhibited an unprecedented 1 fM sensitivity toward TNT in real time, with excellent selectivity over various similar aromatic compounds. Our biomimetic receptor coating approach may be useful for the development of sensitive and selective micro- and nanoelectronic sensor devices for various other target analytes.
微型化智能传感器可以对目标分析物进行敏感和选择性的实时监测，对于各种传感应用具有巨大的价值。我们通过将与共轭聚二乙炔（PDA）聚合物结合的三硝基甲苯（TNT）受体与单壁碳纳米管场效应晶体管（SWNT-FET）相结合，开发了选择性纳米涂层。TNT 分子与噬菌体展示衍生的 TNT 受体之间的选择性结合事件通过 PDA 涂层有效地转化为敏感的 SWNT-FET 电导传感器。所得到的传感器对 TNT 的实时灵敏度达到了前所未有的 1 fM，对各种类似的芳香族化合物具有优异的选择性。我们的仿生受体涂层方法可能有助于开发用于各种其他目标分析物的敏感和选择性微纳电子传感器设备。
