Chatterjee S N, Fiala M, Weiner J, Stewart J A, Stacey B, Warmer N
JAMA. 1978 Nov 24;240(22):2446-9.
Thirty-five renal allograft recipients were studied concerning the relationship between cytomegalovirus (CMV), herpes simplex virus (HSV), and opportunistic bacterial and fungal infections. The incidence of opportunistic infections was determined for patients whose tests prior to transplantation were seronegative in complement fixation and indirect hemagglutination assays of CMV antibody and for those patients whose tests were seropositive. Among the six seronegative patients with seronegative tests, four (66%) experienced active CMV infection within two months, and four died of Candida or Aspergillus infection within six months after transplantation. Among the 22 patients with seropositive tests, only one (4%) had a fungal infection and it was nonfatal (P less than .05). The increased morbidity and mortality due to fungal and bacterial infections in transplant recipients with seronegative CMV tests appears, therefore, to be related to primary CMV infection rather than to generalized immunodeficiency.
对35例肾移植受者进行了关于巨细胞病毒（CMV）、单纯疱疹病毒（HSV）与机会性细菌和真菌感染之间关系的研究。对移植前在CMV抗体补体结合试验和间接血凝试验中血清学阴性的患者以及血清学阳性的患者确定机会性感染的发生率。在6例血清学阴性的患者中，4例（66%）在两个月内发生活动性CMV感染，4例在移植后6个月内死于念珠菌或曲霉菌感染。在22例血清学阳性的患者中，只有1例（4%）发生真菌感染且非致命性（P小于0.05）。因此，CMV血清学阴性的移植受者因真菌和细菌感染导致的发病率和死亡率增加似乎与原发性CMV感染有关，而非与全身性免疫缺陷有关。
