Plastic Surgery Department, University of Witwatersrand, Johannesburg, South Africa.
Wound Repair Regen. 2011 Mar-Apr;19(2):117-33. doi: 10.1111/j.1524-475X.2010.00662.x.
The principles of scar evolution and control are recognized and defined. Further clarity has been shed on these principles with the elucidation and elaboration of the sequence of events occurring at a molecular level. Cellular cross-talk among structures in the cell cytosol, in the cellular nucleus, and outside the cell within in the extracellular matrix is continuous and controlling in nature. This interaction or "dynamic reciprocity" takes place via a series of signals, ionic messenger shifts, protein activation, and receptor transactions. The described principles are now able to be defined in terms of cellular/extracellular matrix interactions and the identification of the cross-talk involved in scar evolution and maturation presents the possibility of influencing the "wording" of this cross-talk to improve scar outcome. The principles of mechanostimulation and scar support, hydration occlusion, controlled inflammation, and collagen/extracellular remodeling are discussed with possible interventions in each category.
认识并定义了瘢痕演变和控制的原则。通过阐明和详细说明分子水平上发生的一系列事件，这些原则更加清晰。细胞溶质、细胞核和细胞外基质中的结构之间的细胞间相互作用是连续的和本质上的控制。这种相互作用或“动态互惠”通过一系列信号、离子信使转移、蛋白质激活和受体转导发生。现在可以根据细胞/细胞外基质相互作用来定义这些原则，并且鉴定涉及瘢痕演变和成熟的相互作用为影响这种相互作用的“措辞”以改善瘢痕结局提供了可能性。本文讨论了机械刺激和瘢痕支持、水合封闭、控制炎症以及胶原/细胞外重塑的原则，并讨论了每个类别中的可能干预措施。
