高水平的抗环瓜氨酸肽自身抗体与类风湿关节炎伴发肺部疾病有关。
High levels of anti-cyclic citrullinated peptide autoantibodies are associated with co-occurrence of pulmonary diseases with rheumatoid arthritis.
机构信息
Service de Rhumatologie, Hôpital Bichat Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France.
出版信息
J Rheumatol. 2011 Jun;38(6):979-82. doi: 10.3899/jrheum.101261. Epub 2011 Mar 1.
OBJECTIVE
To investigate whether levels of anti-cyclic citrullinated peptide antibodies (anti-CCP2) in patients with rheumatoid arthritis (RA) are associated with the co-occurrence of lung diseases.
METHODS
A total of 252 RA patients were included in a cross-sectional study. Pulmonary disease was confirmed by high-resolution chest computed tomography scan. Circulating anti-CCP2 were quantified using ELISA. Multivariate logistic regression was conducted to identify independent risk factors for lung disease.
RESULTS
Male sex (OR 3.29, 95% CI 1.59-6.80) and high anti-CCP2 levels (OR 1.49, 95% CI 1.25-1.78) were identified as independent risk factors for lung disease in the RA population.
CONCLUSION
High anti-CCP2 levels are associated with lung disease in the RA population.
目的
探讨类风湿关节炎（RA）患者的抗环瓜氨酸肽抗体（抗-CCP2）水平是否与肺部疾病的同时发生有关。
方法
采用横断面研究纳入 252 例 RA 患者。通过高分辨率胸部 CT 扫描确认肺部疾病。采用 ELISA 定量检测循环抗-CCP2。采用多变量逻辑回归分析确定肺部疾病的独立危险因素。
结果
男性（OR 3.29，95%CI 1.59-6.80）和高抗-CCP2 水平（OR 1.49，95%CI 1.25-1.78）是 RA 人群肺部疾病的独立危险因素。
结论
高抗-CCP2 水平与 RA 人群的肺部疾病有关。
Zotero 插件