University of Leeds, Chapel Allerton Hospital, Leeds, LS7 4SA, UK.
J Rheumatol. 2011 Mar;38(3):540-5. doi: 10.3899/jrheum.101116.
A composite measure is one way of incorporating an assessment of all relevant clinical outcomes into one single measure. By definition it incorporates several dimensions of disease status often by combining these different domains into a single score. Such instruments are well established in rheumatoid arthritis (RA), and these RA-specific measures have successfully been adopted for use in clinical trials involving patients with psoriatic arthritis (PsA). However, the need for a more PsA-specific composite measure has led to a number of proposals, which, for the large part, incorporate only peripheral articular disease activity. New indices that combine the diverse clinical manifestations of PsA are now under development. These issues were discussed at the 2009 annual meeting of GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis) in Stockholm, Sweden, and are summarized here.
综合指标是将所有相关临床结果评估纳入单一指标的一种方法。根据定义,它包含疾病状态的多个维度,通常通过将这些不同的领域结合成一个单一的分数。这些工具在类风湿关节炎(RA)中已经得到很好的确立,并且这些 RA 特定的指标已经成功地应用于涉及银屑病关节炎(PsA)患者的临床试验中。然而,对更具 PsA 特异性的综合指标的需求导致了许多建议的提出,其中大部分仅纳入外周关节疾病活动。现在正在开发新的综合指数,这些指数结合了 PsA 的多种临床表现。这些问题在瑞典斯德哥尔摩举行的 2009 年 GRAPPA(银屑病和银屑病关节炎研究与评估小组)年会上进行了讨论,现总结如下。