Jurkowlaniec E, Trojniar W, Tokarski J
Department of Animal Physiology, University of Gdańsk.
Acta Physiol Pol. 1990 Nov-Dec;41(7):85-97.
Neocortical and hippocampal EEG activity was recorded in 23 rats subjected to the bilateral electrolytic lesions of the diencephalic zona incerta (ZI). The aim was to find whether damage to ZI can replicate insomnia and disturbances in cortical EEG desynchronization and hippocampal theta rhythm found after lesions of the lateral hypothalamic (LH) area. No effect of the ZI lesions on waking-sleep cycle was found. The amplitude and frequency of cortical waves and hippocampal theta rhythm during waking were changed only in some rats. These changes were small, short-lasting and bidirectional (toward and increase or decrease in different subjects). Both the amplitude and frequency of paradoxical sleep theta were depressed in part of animals. Thus the marked EEG changes after LH lesions can not be attributed to simultaneous damage of the adjacent subthalamic region. However, the ZI seems to constitute a part of a larger system regulating cortical arousal and hippocampal theta rhythm.
对23只大鼠进行间脑未定带（ZI）双侧电解损伤，记录其新皮质和海马的脑电图活动。目的是探究ZI损伤是否能复制下丘脑外侧区（LH）损伤后出现的失眠以及皮质脑电图去同步化和海马θ节律紊乱。未发现ZI损伤对清醒-睡眠周期有影响。仅在部分大鼠中，清醒时皮质波和海马θ节律的振幅及频率发生了变化。这些变化较小、持续时间短且呈双向性（不同个体有增加或减少）。部分动物的异相睡眠θ波的振幅和频率均降低。因此，LH损伤后明显的脑电图变化不能归因于相邻的丘脑底区域同时受损。然而，ZI似乎构成了调节皮质觉醒和海马θ节律的更大系统的一部分。
